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In controlled clinical trials conducted with another formulation of methotrexate in rheumatoid arthritis n 128 , leukopenia wbc 3000 mm was seen in 2 patients, thrombocytopenia platelets 100,000 mm in 6 patients, and pancytopenia in 2 patients.
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the fda has approved a self-injection device for the subcutaneous administration of methotrexate, manufacturer antares pharma announced today.
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